Use of paracetamol for the treatment of patent ductus arteriosus in premature Newborns: A systematic review

Objective: Patent ductus arteriosus is associated with multiple complications and high neonatal mortality. This study aimed to evaluate the efficacy benefits of paracetamol compared ibuprofen indomethacin, non-steroidal anti-inflammatory drugs usually used close in premature newborns. Data source: We searched PubMed, SciELO, Lilacs, Bireme, ClinicalTrials.gov Embase databases for articles published between January 2005 December 2020. The descriptors were: newborn, patent arteriosus, pharmacotherapy, closure / acetaminophen. quality was evaluated by classification Oxford Centre Evidence based Medicine. synthesis: comparable that it lower rates gastrointestinal intracerebral hemorrhage, spontaneous intestinal perforation, thrombocytopenia, hepatic renal intolerance, serum values urea, creatinine, bilirubin. Furthermore, more advantageous than placebo or nonintervention may be best option cases contraindications other drugs. Gestational age birth weight were factors influenced showed reduced extremely newborns low very weights. Conclusions: Other clinical prospective studies are needed support indication arteriosus. However, this drug proves a promising pharmacological alternative, having similar classic drugs, fewer adverse effects.